PINK1
PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene. It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria. PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson's disease.
Animal models of Parkinson's diseaseAutophagyBump and holeCauses of Parkinson's diseaseChromosome 1FBXO7HSH2DHistory of Parkinson's diseaseList of OMIM disorder codesList of human protein-coding genes 3MFN2Miratul MuqitMitochondria associated membranesMitophagyNiclosamidePARLPINK1 (gene)PTEN-induced putative kinasePTEN-induced putative kinase 1Parkin (ligase)Parkinson's_diseasePathophysiology of Parkinson's diseaseProtein kinase domainRHOT1RHOT2
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PINK1
PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene. It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria. PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson's disease.
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PTEN-induced kinase 1 (PINK1) ...... rly-onset Parkinson's disease.
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PTEN-induced kinase 1 (PINK1) ...... rly-onset Parkinson's disease.
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PINK1
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