PR-104
PR-104 is a drug from the class of hypoxia-activated prodrugs (HAPs), which is being researched as a potential anti-cancer therapeutic agent. It is a phosphate ester “pre-prodrug” that is rapidly converted to the HAP PR-104A in the body. PR-104A is in turn metabolised to reactive nitrogen mustard DNA crosslinking agents in hypoxic tissues such as found in solid tumours. Following initial clinical studies, it was discovered that PR-104A is also activated by the enzyme AKR1C3, independently of hypoxia. Hypoxia in the bone marrow of patients with leukaemia, and high activity of AKR1C3 in some leukaemia subtypes has led to interest in clinical trials of PR-104 in relapsed refractory acute leukaemias.
Wikipage disambiguates
Link from a Wikipage to another Wikipage
primaryTopic
PR-104
PR-104 is a drug from the class of hypoxia-activated prodrugs (HAPs), which is being researched as a potential anti-cancer therapeutic agent. It is a phosphate ester “pre-prodrug” that is rapidly converted to the HAP PR-104A in the body. PR-104A is in turn metabolised to reactive nitrogen mustard DNA crosslinking agents in hypoxic tissues such as found in solid tumours. Following initial clinical studies, it was discovered that PR-104A is also activated by the enzyme AKR1C3, independently of hypoxia. Hypoxia in the bone marrow of patients with leukaemia, and high activity of AKR1C3 in some leukaemia subtypes has led to interest in clinical trials of PR-104 in relapsed refractory acute leukaemias.
has abstract
PR-104 is a drug from the clas ...... d refractory acute leukaemias.
@en
CAS number
851627-62-8
FDA UNII code
V16D2ZT7DT
PubChem
Wikipage page ID
50,135,290
page length (characters) of wiki page
Wikipage revision ID
983,808,809
Link from a Wikipage to another Wikipage
CAS number
ChemSpiderID
IUPAC name
[2-ethoxy]phosphonic acid
@en
PubChem
11,455,973
SMILES
CSOCCNc1cCNCCOPO
@en
StdInChIKey
GZSOKPMDWVRVMG-UHFFFAOYSA-N
@en
UNII
V16D2ZT7DT
@en
wikiPageUsesTemplate
comment
PR-104 is a drug from the clas ...... d refractory acute leukaemias.
@en
label
PR-104
@en