Panama sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. This was the nation's seventh time competing in the Summer Paralympic Games after it first entered the movement at the 1992 Summer Paralympics. The Panamanian delegation to Rio de Janeiro consisted of two athletes: shot put thrower Francisco Cedeño Almengor and javelin thrower Iveth Valdes Romero. Almengor ranked eleventh out of twelve athletes in the men's shot put F54–55 competition and Romero placed in the same position in the women's javelin F55–F56 event.