The Penn Wells Hotel in Wellsboro, Pennsylvania, is listed on the National Registry of the Historic Hotels of America. It was built in 1829 and was expanded and renovated in the 1920s. It suffered a fire in 1906. It was once known as . "The Penn Wells Hotel sits as the centerpiece of Wellsboro, Pennsylvania's gaslit Main Street historic district." It is located on Pennsylvania Route 6, which at one time was the Roosevelt Highway, the main route between New York City and Chicago, bringing much business to the hotel.