Philadelphia chromosome
The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells). This chromosome is defective and unusually short because of reciprocal translocation, t(9;22)(q34;q11), of genetic material between chromosome 9 and chromosome 22, and contains a fusion gene called BCR-ABL1. This gene is the ABL1 gene of chromosome 9 juxtaposed onto the breakpoint cluster region BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signalling protein that is "always on", causing the cell to divide uncontrollably by interrupting the stability of the genome and impairing various signaling pathways governing the cell cycle.
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1,2-dimethoxyethaanAcute basophilic leukemiaAcute lymphoblastic leukemiaAntineoplastic resistanceAtypical chronic myeloid leukemiaAutologous immune enhancement therapyAxitinibBCR-ABLBCR-AblBCR/ABLBCRABLBCR (gene)1,2-dimethoxyethaanBcl-AbrBcr-AblBcr-Abl tyrosine-kinase inhibitorBcr-ablBcr-abl fusion proteinBcr:ablBiphenotypic acute leukaemiaBispecific monoclonal antibodyBlinatumomabBosutinibCancerCancer biomarkerCarcinogenesisChemotherapyChristine HarrisonChromosomal translocationChromosome 22Chromosome 9Chronic myelogenous leukemiaChronic myelomonocytic leukemiaChronic neutrophilic leukemiaClara D. BloomfieldClonal hypereosinophiliaCruciferous vegetablesCytogeneticsDasatinibDavid Hungerford
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Philadelphia chromosome
The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells). This chromosome is defective and unusually short because of reciprocal translocation, t(9;22)(q34;q11), of genetic material between chromosome 9 and chromosome 22, and contains a fusion gene called BCR-ABL1. This gene is the ABL1 gene of chromosome 9 juxtaposed onto the breakpoint cluster region BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signalling protein that is "always on", causing the cell to divide uncontrollably by interrupting the stability of the genome and impairing various signaling pathways governing the cell cycle.
has abstract
BCR-ABL — гибридный белок (анг ...... этих ингибиторов был иматиниб.
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Chromosom Philadelphia, chromo ...... izmie (na przykład dasatynib).
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Cromossomo Filadélfia ou trans ...... ue foi descoberto, Filadélfia.
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El cromosoma Filadelfia, tambi ...... o o cromosoma de Filadelfia.
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Het Philadelphiachromosoom is ...... receptor zelf wordt gekeken).
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Il cromosoma Philadelphia uman ...... golarmente la molecola stessa.
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Le chromosome Philadelphie est ...... ie aigüe myéloblastique (LAM).
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Philadelphiakromosom är en gen ...... ed denna genetiska förändring.
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Philadelphský chromozom je def ...... lphia, kde byl poprvé objeven.
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The Philadelphia chromosome or ...... enotype acute leukemia (MPAL).
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1,021,469,018
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caption
A metaphase cell positive for the bcr/abl rearrangement using FISH
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MeshID
D010677
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name
Philadelphia chromosome
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BCR-ABL — гибридный белок (анг ...... еста прерывания BCR-фрагмента.
@ru
Chromosom Philadelphia, chromo ...... yczynę powstania tej anomalii.
@pl
Cromossomo Filadélfia ou trans ...... ue foi descoberto, Filadélfia.
@pt
El cromosoma Filadelfia, tambi ...... o o cromosoma de Filadelfia.
@es
Het Philadelphiachromosoom is ...... n worden aangekleurd in de chr
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Il cromosoma Philadelphia uman ...... are alterazioni proliferative.
@it
Le chromosome Philadelphie est ...... me le gène de fusion BCR-ABL1.
@fr
Philadelphiakromosom är en gen ...... ed denna genetiska förändring.
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Philadelphský chromozom je def ...... lphia, kde byl poprvé objeven.
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The Philadelphia chromosome or ...... ways governing the cell cycle.
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label
Bcr-Abl
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Chromosom Philadelphia
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Chromosome de Philadelphie
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Cromosoma Filadelfia
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Cromosoma Philadelphia
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Cromossomo Filadélfia
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Philadelphia chromosome
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Philadelphia-Chromosom
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Philadelphiachromosoom
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Philadelphiakromosom
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Philadelphia chromosome
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