Phylo is an experimental video game about multiple sequence alignment optimisation. Developed by the McGill Centre for Bioinformatics, it was originally released as a free Flash game in November 2010. Designed as a game with a purpose, players solve pattern-matching puzzles that represent nucleotide sequences of different phylogenetic taxa to optimize alignments over a computer algorithm. By aligning together each nucleotide sequence, represented as differently coloured blocks, players attempt to create the highest point value score for each set of sequences by matching as many colours as possible and minimizing gaps.