Pier Paolo Crescenzi (1572 – 19 February 1645) was an Italian Catholic cardinal. Crescenzi was born in 1572, the son of Virgilio Crescenzi, Baron of Montorio, and Costanza del Drago, of the Marquises of Riofreddo. He was the brother of artist Giovanni Battista Crescenzi. He was educated at the University of Perugia and earned a doctorate in utroque iure (Civil and Canon Law). While bishop, he was the principal consecrator of Malatesta Baglioni, Bishop of Pesaro (1612).