Radical SAM
Radical SAM is a designation for a superfamily of enzymes that use a [4Fe-4S]+ cluster to reductively cleave S-adenosyl-L-methionine (SAM) to generate a radical, usually a 5′-deoxyadenosyl radical, as a critical intermediate. These enzymes utilize this potent radical intermediate to perform an array of unusual (from the perspective of organic chemistry) transformations, often to functionalize unactivated C-H bonds. Radical SAM enzymes are involved in cofactor biosynthesis, enzyme activation, peptide modification, post-transcriptional and post-translational modifications, metalloprotein cluster formation, tRNA modification, lipid metabolism, biosynthesis of antibiotics and natural products etc. The vast majority of known radical SAM enzymes belong to the , and have a cysteine-rich motif tha
(Formate-C-acetyltransferase)-activating enzyme4-Amino-5-hydroxymethyl-2-methylpyrimidineAdenosineBiotin synthaseBottromycinDarobactinDeoxyadenosyl radicalFormate C-acetyltransferaseFormylglycine-generating enzymeGlutamate 2,3-aminomutaseHopanoidsIron–sulfur proteinJoan B. BroderickKedarcidinLipoic acidLipoyl synthaseLysine 2,3-aminomutaseMethionineMethyl radicalMethylornithine synthaseMethylthiotransferase1,2-dimethoxyethaanMycofactocin1,2-dimethoxyethaanR. David BrittS-Adenosyl methionineSpore photoproduct lyase
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Radical SAM
Radical SAM is a designation for a superfamily of enzymes that use a [4Fe-4S]+ cluster to reductively cleave S-adenosyl-L-methionine (SAM) to generate a radical, usually a 5′-deoxyadenosyl radical, as a critical intermediate. These enzymes utilize this potent radical intermediate to perform an array of unusual (from the perspective of organic chemistry) transformations, often to functionalize unactivated C-H bonds. Radical SAM enzymes are involved in cofactor biosynthesis, enzyme activation, peptide modification, post-transcriptional and post-translational modifications, metalloprotein cluster formation, tRNA modification, lipid metabolism, biosynthesis of antibiotics and natural products etc. The vast majority of known radical SAM enzymes belong to the , and have a cysteine-rich motif tha
has abstract
Radical SAM is a designation f ...... he largest enzyme superfamily.
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Symbol
Radical_SAM
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36,467,539
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1,025,904,696
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InterPro
IPR007197
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name
Radical_SAM
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Pfam
PF04055
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SCOP
symbol
Radical_SAM
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subject
hypernym
comment
Radical SAM is a designation f ...... have a cysteine-rich motif tha
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label
Radical SAM
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