Reelin
Reelin (RELN) is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. It also stimulates dendrite and dendritic spine development and regulates the continuing migration of neuroblasts generated in adult neurogenesis sites like the subventricular and subgranular zones. It is found not only in the brain but also in the liver, thyroid gland, adrenal gland, Fallopian tube, breast and in comparatively lower levels across a range of anatomical regions.
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1995 in scienceADAMTS3Adapter molecule crk1,2-dimethoxyethaanAnimal model of schizophreniaAstrocyteBNR/Asp-box repeatBrain-derived neurotrophic factorCRKLCRMP1CUL5Cajal–Retzius cellCerebral cortexCerebral organoidCofilin 1Cyclin-dependent kinase 5DAB1DGCR2DSCAMDevelopment of the cerebral cortexDouglas Scott FalconerEndophenotypeEpigenetics in learning and memoryEpigenetics of schizophreniaErminio CostaFABP7Glucocorticoids in hippocampal developmentGlutamate decarboxylaseGranule cell dispersionGuidepost cellsHepatic stellate cellHeritability of autismHossein Fatemi (psychiatrist)Human accelerated region 1HypoplasiaIntegrin alpha 3Integrin beta 1Laboratory ratLissencephalyList of OMIM disorder codes
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Reelin
Reelin (RELN) is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. It also stimulates dendrite and dendritic spine development and regulates the continuing migration of neuroblasts generated in adult neurogenesis sites like the subventricular and subgranular zones. It is found not only in the brain but also in the liver, thyroid gland, adrenal gland, Fallopian tube, breast and in comparatively lower levels across a range of anatomical regions.
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Reelin (RELN) is a large secre ...... linked to psychotic disorders.
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September 2017
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Reelin (RELN) is a large secre ...... a range of anatomical regions.
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Reelin
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