SH-053-R-CH3-2′F
SH-053-R-CH3-2′F is a drug used in scientific research which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more subtype-selective than most other drugs of this class, having high selectivity, binding affinity and efficacy at the α5 subtype of the GABAA receptor. This gives much tighter control of the effects produced, and so while SH-053-R-CH3-2′F retains sedative and anxiolytic effects, it does not cause ataxia at moderate doses. SH-053-R-CH3-2′F also blocks the nootropic effects of the α5-selective inverse agonist PWZ-029, so amnesia is also a likely side effect.
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SH-053-R-CH3-2′F
SH-053-R-CH3-2′F is a drug used in scientific research which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more subtype-selective than most other drugs of this class, having high selectivity, binding affinity and efficacy at the α5 subtype of the GABAA receptor. This gives much tighter control of the effects produced, and so while SH-053-R-CH3-2′F retains sedative and anxiolytic effects, it does not cause ataxia at moderate doses. SH-053-R-CH3-2′F also blocks the nootropic effects of the α5-selective inverse agonist PWZ-029, so amnesia is also a likely side effect.
has abstract
SH-053-R-CH3-2′F is a drug use ...... fficacy, and kinetic behavior.
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CAS number
872874-14-1
PubChem
Wikipage page ID
22,232,677
page length (characters) of wiki page
Wikipage revision ID
1,014,829,476
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CAS number
ChemSpiderID
IUPAC name
PubChem
11,574,585
SMILES
Fc2ccccc2C1=NCc3cncn3-cc1cc4C#C
@en
StdInChIKey
NGYKELBMVXBFSM-CQSZACIVSA-N
@en
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subject
hypernym
comment
SH-053-R-CH3-2′F is a drug use ...... is also a likely side effect.
@en
label
SH-053-R-CH3-2′F
@en