SV40 large T antigen
SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function.
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293TBiological immortalityCOS cellsHEK 293 cellsJacalin-like lectin domainKaryopherin alpha 2LTLarge tumor antigenNuclear localization sequenceOrigin of replication1,2-dimethoxyethaanRobert TjianSV40SV40TSV40 Large T-antigenSV40 TAgSV40 large T-antigenSara A. CourtneidgeSara MoleSimian virus 40 large T-antigenStreptococcus pyogenesT-antigenT antigenTarget peptide
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SV40 large T antigen
SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function.
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SV40 large T antigen (Simian V ...... being used to grow Sabin OPV.
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1,023,562,567
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SV40 T helicase domain hexamer, Simian virus.
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Organism
Simian virus 40
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UniProt
P03070
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SV40 large T antigen (Simian V ...... o its transformation function.
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SV40 large T antigen
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