Sakai Masahisa (坂井 政尚, died November 26, 1570) was a Japanese samurai of the Sengoku Period, who most notably served the Oda clan. He was born in Mino Province, and first served the Saitō clan. After the fall of the Saitō, he was taken on as a retainer by Oda Nobunaga. He was particularly active during the time of Oda Nobunaga's entry into Kyoto. In late 1568, Masahisa joined Shibata Katsuie, Hosokawa Fujitaka, Hachiya Yoritaka, and Mori Yoshinari in attacking Iwanari Tomomichi's Shōryūji Castle.