The Samuel Smith House and Tannery is a historic residence in the village of Greenfield, Ohio, United States. Built in the 1820s, it has been named a historic site. Greenfield was founded by American Revolution veteran William Robinson Smith, a native of Pennsylvania, in 1812. Smith and his son Robert founded a tannery on the settlement's eastern edge, along Paint Creek, and built a vernacular building to house the business. After several years of operation, the tannery was taken over by William's oldest son Samuel M., who arranged for the destruction of the original building and the construction of the present house in its stead. As the years passed, Samuel Smith became a prominent physician.