Highway 52 is a highway in the Canadian province of Saskatchewan. It runs from Highway 15 / Highway 310 near Ituna to Highway 10A in Yorkton near . Highway 52 is about 70 km (43 mi) long. Highway 52 connects with Highways 617, 651, and 47. It also carries a short concurrency with Highway 310 for 1.6 km (1.0 mi) to its western terminus; Highway 310 continues its concurrency with Highway 15 south of the junction. The communities of Homefield, Willowbrook, , , and are near the highway between Highway 15 and Yorkton.