Seán Silke (born 27 September 1950) is an Irish retired hurler who played as a centre-back for the Galway senior team. Born in Meelick, County Galway, Silke first played competitive hurling in his youth. He made his first impression on the inter-county scene when he made his senior debut during the 1971-72 National Hurling League. Silke went on to play a key role for Galway for over a decade, and won one All-Ireland medal and one National Hurling League medal. He was an All-Ireland runner-up on three occasions.