Sinnipee (also called Sinipee) is a former settlement in Grant County, Wisconsin, United States. Sinnipee was a port community on the Mississippi River at the mouth of the ; it played a significant role in the lead trade. The community was first settled prior to 1832 by Payton Vaughan of North Carolina and was founded by the Sinnipee Company in 1835. A hotel called the Old Stone House opened in the community in 1839; both US president Zachary Taylor and Confederate president Jefferson Davis stayed at the hotel during its operation. The community suffered a flood and an outbreak of fever in 1840, which hurt the town's businesses; all but two families left Sinnipee, and by 1859, only one building remained in the town's business district. After a fire, the hotel was dismantled to build a dam