Sir Edward Littleton, 1st Baronet (c. 1599 – c. 1657) was a 17th-century English Baronet and politician from the extended Littleton/Lyttelton family, the first of a line of four Littleton baronets with Pillaton Hall as their seat. He initially joined the Parliamentarians during the English Civil War. Having tried unsuccessfully to find a third way, he switched his support to the Royalist cause – a decision that led to his financial ruin, as large debts made it impossible to redeem his estates from sequestration after the victory of Parliament.