Sir George Barlow 2nd Baronet (c. 1680–1726) of Slebech, Pembrokeshire was a British landowner and politician who sat in the House of Commons from 1713 to 1715. Barlow was the eldest son of Sir John Barlow, 1st Baronet of Slebech and his second wife Catherine Middleton, daughter of Christopher Middleton of Middleton Hall, Carmarthenshire. He was from a South Wales Catholic family with Jacobite and High Tory sentiments. He married Winifred Heneage, daughter of George Heneage of Hainton Hall, Lincolnshire on 31 May 1695 and succeeded his father in the baronetcy when his will was proved on 27 June 1695. The marriage brought him lands, but the young Lady Barlow eloped from her husband after their only child was born.