Sir James Smyth, 1st Baronet (c. 1686 – 28 February 1717) was a baronet in the Baronetage of Great Britain. He was the only son of Alderman Sir James Smyth, a London draper and Lord Mayor of London, 1684–85, by his second wife, Elizabeth, daughter and co-heir of Arthur Shirley of Isfield, Sussex. Alderman Smyth was the second son of Sir Robert Smyth, 1st Baronet of Upton, Essex. He married Elizabeth Shirley in June 1682, and died aged 72 on 9 December 1706.