Six of One is a 1978 novel by Rita Mae Brown. It is the first in her Runnymede series of book about a small town on the Mason-Dixon line and its sometimes eccentric residents. It is also the first of the Hunsenmeir trilogy, a subset of the Runnymede series, which focuses on the elderly Hunsenmeir sisters. According to Brown, the sisters are based on her own mother and aunt, who "do tend to dominate in a way", and the town is based on her own birthplace, about which she says: "It’s really interesting to have one foot in the North and one foot in the South."