St Andrew St John, 16th Baron St John of Bletso (5 October 1840 – 2 November 1887) was an English peer. St John was the eldest son of St Andrew Beauchamp St John, 15th Baron St John and his wife Eleanor Hussey. He succeeded his father to become the 16th Lord St John, in 1874 and lived at Melchbourne. Politically he was a Conservative. St John died at Melchbourne at the age of 46 from congestion of the lungs and was buried at Bletsoe. He had no male child and the title passed to his younger brother Beauchamp.