St Mary's Roman Catholic Church is a heritage-listed church at 271–275 Adelaide Street, Maryborough, Fraser Coast Region, Queensland, Australia, on land donated to the Church by Maryborough pioneer James Cleary. It was initially designed by Charles Tiffin with later additions and alterations by Francis Drummond Greville Stanley and POE Hawkes. The initial construction was from 1869 to 1872 by G Smith and J Thomas. It was added to the Queensland Heritage Register on 21 October 1992.