Suicide inhibition
In biochemistry, suicide inhibition, also known as suicide inactivation or mechanism-based inhibition, is an irreversible form of enzyme inhibition that occurs when an enzyme binds a substrate analog and forms an irreversible complex with it through a covalent bond during the normal catalysis reaction. The inhibitor binds to the active site where it is modified by the enzyme to produce a reactive group that reacts irreversibly to form a stable inhibitor-enzyme complex. This usually uses a prosthetic group or a coenzyme, forming electrophilic alpha and beta unsaturated carbonyl compounds and imines.
7α-ThiospironolactoneAGT IIAffinity labelAspirinChemical biologyCimetidineClavulanic_acidCombination antibioticDutasterideEflornithineEnzyme inhibitorExemestaneGranzyme BJoAnne StubbeLanosterol synthaseLewisiteMaspinMechanism-based inhibitionMechanism-based inhibitorMechanism based inhibitionMechanism based inhibitorMelarsoprolO-6-methylguanine-DNA methyltransferaseO6-BenzylguaninePlasminogen activator inhibitor-2Protease inhibitor (biology)SerpinSteroidal aromatase inhibitorSubstrate analogSuicide enzymeSuicide inhibitorSuicide substrateTransition state analogURA3VigabatrinΒ-Lactamase inhibitor
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Suicide inhibition
In biochemistry, suicide inhibition, also known as suicide inactivation or mechanism-based inhibition, is an irreversible form of enzyme inhibition that occurs when an enzyme binds a substrate analog and forms an irreversible complex with it through a covalent bond during the normal catalysis reaction. The inhibitor binds to the active site where it is modified by the enzyme to produce a reactive group that reacts irreversibly to form a stable inhibitor-enzyme complex. This usually uses a prosthetic group or a coenzyme, forming electrophilic alpha and beta unsaturated carbonyl compounds and imines.
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In biochemistry, suicide inhib ...... carbonyl compounds and imines.
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Un inibitore suicida (o inatti ...... tore enzimatico irreversibile.
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In biochemistry, suicide inhib ...... carbonyl compounds and imines.
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Un inibitore suicida (o inatti ...... tore enzimatico irreversibile.
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Inibitore suicida
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Suicide inhibition
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