Sulphur Creek is a stream in eastern Iron County in the U.S. state of Missouri. It is a tributary of Crane Pond Creek. The stream headwaters arise at 37°25′13″N 90°38′40″W / 37.42028°N 90.64444°W and the confluence with Crane Pond Creek is at 37°22′06″N 90°34′58″W / 37.36833°N 90.58278°W.The source area is in Clark National Forest and the stream flows south and southeast out of the forest area. It passes under Missouri Route C before its confluence with Crane Pond Creek south of the community of Minimum.