Talin (protein)
Talin is a high-molecular-weight cytoskeletal protein concentrated at regions of cell–substratum contact and, in lymphocytes, at cell–cell contacts. Discovered in 1983 by Keith Burridge and colleagues, talin is a ubiquitous cytosolic protein that is found in high concentrations in focal adhesions. It is capable of linking integrins to the actin cytoskeleton either directly or indirectly by interacting with vinculin and α-actinin.
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Actin-binding proteinAlan HallCell adhesionDurotaxisElasticity of cell membranesExtracellular matrixFERMT3FERM domainFocal adhesionGrowth coneImmunological synapseIndex of biochemistry articlesIndex of biophysics articlesIntegrinKeith BurridgeLDB3Leukocyte extravasationList of MeSH codes (D12.776)MechanotransductionMorphogenesisNancy HoggNodularinPTK2PaxillinProtein–protein interactionTLN1TLN2TalinTalin proteinVLA-4VinculinVinculin family
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primaryTopic
Talin (protein)
Talin is a high-molecular-weight cytoskeletal protein concentrated at regions of cell–substratum contact and, in lymphocytes, at cell–cell contacts. Discovered in 1983 by Keith Burridge and colleagues, talin is a ubiquitous cytosolic protein that is found in high concentrations in focal adhesions. It is capable of linking integrins to the actin cytoskeleton either directly or indirectly by interacting with vinculin and α-actinin.
has abstract
Talin is a high-molecular-weig ...... lin promotes vinculin binding.
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Talina es una proteína de alto ...... ial y las etapas de invasión.
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locus supplementary data
OMIM id
RefSeq
Symbol
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Wikipage page ID
10,499,292
page length (characters) of wiki page
Wikipage revision ID
1,004,398,027
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AltSymbols
TLN
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Arm
p
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q
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caption
human vinculin head in complex with talin's vinculin binding site 3
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EntrezGene
InterPro
IPR015009
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IPR015224
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LocusSupplementaryData
-p21
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-q21
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PDB
B:607–631 B:491–652 A:491–652
B:605–628
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Pfam
PF08913
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PF09141
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RefSeq
NM_006289
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NM_015059
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symbol
UniProt
Q9Y490
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Q9Y4G6
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wikiPageUsesTemplate
subject
comment
Talin is a high-molecular-weig ...... g with vinculin and α-actinin.
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Talina es una proteína de alto ...... la vinculina y alfa-actinina.
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label
Talin (protein)
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Talina
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wasDerivedFrom
isPrimaryTopicOf
name
talin 1
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talin 2
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