Tallassee (also "Talassee," "Talisi," "Tellassee," and various similar spellings) is a prehistoric and historic Native American site in present-day Blount and Monroe counties, Tennessee in the southeastern United States. Tallassee (Cherokee: ᏔᎵᏏ, romanized: Talisi) was the southernmost (and furthest upriver) of a string of Overhill Cherokee towns that existed along the lower Little Tennessee River on the west side of the Appalachian Mountains in the 18th century. Although Tallassee receives scant attention in primary historical accounts, it is one of the few Overhill towns to be shown on every major 18th-century map of the Little Tennessee Valley.