Telomestatin
Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of in vitro cancer cells. It was first isolated from the bacteria Streptomyces anulatus. Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.
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Telomestatin
Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of in vitro cancer cells. It was first isolated from the bacteria Streptomyces anulatus. Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.
has abstract
Telomestatin is a macrocyclic ...... e to Hayflick type senescence.
@en
テロメスタチン(telomestatin)は、がん細胞のテロ ...... が、非天然型の (S)-体の方がテロメラーゼ阻害活性が高い。
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IUPAC name
(84R)-65,75-Dimethyl-84,85-dih ...... 4)-[1,3]thiazolocyclooctaphane
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25,372,051
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1,020,524,622
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400,875,358
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comment
Telomestatin is a macrocyclic ...... e to Hayflick type senescence.
@en
テロメスタチン(telomestatin)は、がん細胞のテロ ...... が、非天然型の (S)-体の方がテロメラーゼ阻害活性が高い。
@ja
label
Telomestatin
@en
テロメスタチン
@ja