Tetratricopeptide repeat
The tetratricopeptide repeat (TPR) is a structural motif. It consists of a degenerate 34 amino acid tandem repeat identified in a wide variety of proteins. It is found in tandem arrays of 3–16 motifs, which form scaffolds to mediate protein–protein interactions and often the assembly of multiprotein complexes. These alpha-helix pair repeats usually fold together to produce a single, linear solenoid domain called a TPR domain. Proteins with such domains include the anaphase-promoting complex (APC) subunits cdc16, cdc23 and cdc27, the NADPH oxidase subunit p67-phox, hsp90-binding immunophilins, transcription factors, the protein kinase R (PKR), the major receptor for peroxisomal matrix protein import PEX5, protein arginine methyltransferase 9 (PRMT9), and mitochondrial import proteins.
14-3-3 proteinANAPC7Alpha solenoidBBS4BUB1BtpA proteinCDC23CDC27COA7DYX1C1EIF-W2 protein domainEndoplasmic reticulum membrane protein complexFIS1FKBP4Glutamate-rich protein 4HSP90AB1Housekeeping geneIFIT proteinsKinesinMagnetotactic bacteriaNAA15O-GlcNAcPentatricopeptide repeatPeptidylprolyl isomerase DPoribacteriaProtein O-GlcNAc transferaseRopB transcriptional regulatorRoxan (protein)SH3TC2SPATA16Solenoid protein domainTMTC4TPRTTC19TTC28TTC4TetratricopeptideTetratricopeptide repeat 39ATetratricopeptide repeat domainTetratricopeptide repeat domain 16 isoform 1
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Tetratricopeptide repeat
The tetratricopeptide repeat (TPR) is a structural motif. It consists of a degenerate 34 amino acid tandem repeat identified in a wide variety of proteins. It is found in tandem arrays of 3–16 motifs, which form scaffolds to mediate protein–protein interactions and often the assembly of multiprotein complexes. These alpha-helix pair repeats usually fold together to produce a single, linear solenoid domain called a TPR domain. Proteins with such domains include the anaphase-promoting complex (APC) subunits cdc16, cdc23 and cdc27, the NADPH oxidase subunit p67-phox, hsp90-binding immunophilins, transcription factors, the protein kinase R (PKR), the major receptor for peroxisomal matrix protein import PEX5, protein arginine methyltransferase 9 (PRMT9), and mitochondrial import proteins.
has abstract
The tetratricopeptide repeat ( ...... mitochondrial import proteins.
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Symbol
Wikipage page ID
21,935,881
page length (characters) of wiki page
Wikipage revision ID
997,538,937
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CDD
cd00189
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InterPro
IPR001440
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name
Tetratricopeptide repeat
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PDB
B:89-122 A:522-555 B:228- ...... 1-104 A:351-384 A:351-384
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Pfam
PF00515
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Pfam clan
CL0020
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symbol
TPR_1
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wikiPageUsesTemplate
subject
comment
The tetratricopeptide repeat ( ...... mitochondrial import proteins.
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label
Tetratricopeptide repeat
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