Thomas Mitchell Buffington was born October 15, 1855, in Going Snake District of the Cherokee Nation, Indian Territory, now in Adair County, Oklahoma. His parents were Ezekiel Buffington, who was born in Georgia in 1807 and settled in Oklahoma Territory in 1835 as part of the Cherokee diaspora. His mother was Louisa (Newman) Buffington, who was born in Tennessee in 1817 and died in 1898. Buffington was one of eight children. Buffington married Susie Woodall in 1878 (b.1857-d.1891); she was a school teacher. Four years after his first wife's death, he married E. Gray, a teacher in the Cherokee schools.