Top7
Top7 is an artificial 93-residue protein, classified as a de novo protein since it was designed by Brian Kuhlman and Gautam Dantas in David Baker's laboratory at the University of Washington to have a unique fold not found in nature. The protein was designed ab initio on a computer with the help of protein structure prediction algorithms. Determination of the high-resolution X-ray structure of the experimentally expressed and purified protein revealed that the structure (PDB ID: 1QYS) was indeed very similar (1.2 Å RMSD) to the computer-designed model. The structure consists of two alpha helices packed on a five-stranded anti-parallel beta sheet.
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Top7
Top7 is an artificial 93-residue protein, classified as a de novo protein since it was designed by Brian Kuhlman and Gautam Dantas in David Baker's laboratory at the University of Washington to have a unique fold not found in nature. The protein was designed ab initio on a computer with the help of protein structure prediction algorithms. Determination of the high-resolution X-ray structure of the experimentally expressed and purified protein revealed that the structure (PDB ID: 1QYS) was indeed very similar (1.2 Å RMSD) to the computer-designed model. The structure consists of two alpha helices packed on a five-stranded anti-parallel beta sheet.
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Top7 es una proteína artificia ...... as en el logo de Rosetta@home.
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Top7 is an artificial 93-resid ...... ured in the Rosetta@home logo.
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Top7 es una proteína artificia ...... de cinco varas anti-paralelas.
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Top7 is an artificial 93-resid ...... nded anti-parallel beta sheet.
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Top7
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Top7
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