Twyford and Stenson is a civil parish in the South Derbyshire district of Derbyshire, England. Located south of Derby on the Trent and Mersey Canal, it consists of two villages, Stenson and its smaller neighbour Twyford. A railway line follows the line of the canal, part of a loop for freight bypassing Derby. This runs from the nearby Stenson Junction on the Derby-Birmingham line to Sheet Stores Junction at Sawley on the Midland Main Line.