USS Murphy (DD-603) was a Benson-class destroyer in the United States Navy during World War II. She was named for Lieutenant John McLeod Murphy. Murphy's keel was laid down 19 May 1941 by Bethlehem Steel Corporation at their shipyard in Staten Island, New York. The destroyer was launched on 29 April 1942, sponsored by Miss M. Elsie Murphy, daughter of Lieutenant Murphy. The vessel was commissioned on 25 July 1942, Commander Leonard W. Bailey in command.