Vakhtang I (Georgian: ვახტანგ I მუხრანბატონი, Vakhtang I Mukhranbatoni) (1511 – 1 October 1580) was a Georgian tavadi ("prince") of the House of Mukhrani, a collateral branch of the royal Bagrationi dynasty of Kartli, and Prince (batoni) of Mukhrani from 1539 until his death. At the same time, he was an ex officio commander of the Banner of Shida Kartli. In the absence of his relative, King Simon I of Kartli, in the captivity in Safavid Iran, Vakhtang was installed by the nobility as a regent in opposition to the pro-Safavid regime of Daud-Khan from 1569 to 1579.