Vakhtang I Gurieli (Georgian: ვახტანგ I გურიელი; died 1587), of the House of Gurieli, was Prince of Guria from 1583 to 1587. He ruled Guria, a small state in southwestern Georgia, as a client of Mamia IV Dadiani, Prince of Mingrelia, who had deposed Giorgi II Gurieli. Vakhtang was one of the sponsors of the Shemokmedi Monastery, Guria's principal cathedral.