Variant surface glycoprotein
Variant surface glycoprotein (VSG) is a ~60kDa protein which densely packs the cell surface of protozoan parasites belonging to the genus Trypanosoma. This genus is notable for their cell surface proteins. They were first isolated from Trypanosoma brucei in 1975 by George Cross. VSG allows the trypanosomatid parasites to evade the mammalian host's immune system by extensive antigenic variation. They form a 12–15 nm surface coat. VSG dimers, ~90% of all cell surface protein. It also makes up ~10% of total cell protein. For this reason, these proteins are highly immunogenic and an immune response raised against a specific VSG coat will rapidly kill trypanosomes expressing this variant. However, with each cell division there is a possibility that the progeny will switch expression to change t
Bloodstream Expression SiteBloodstream expression siteExpression Site Associated GeneExpression site associated geneTb05.26C7.380Tb927.5.4730VSG proteinVSG proteinsVariable Surface GlycoproteinVariable Surface GlycoproteinsVariable surface glycoproteinVariable surface glycoproteinsVariant Surface GlycoproteinVariant Surface GlycoproteinsVariant surface glycoproteinsVariant surface glycoproteins, trypanosoma
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African trypanosomiasisAntigenic escapeAntigenic variationBESBloodstream Expression SiteBloodstream expression siteCoat proteinCovering sicknessESAGExpression Site Associated GeneExpression site associated geneGeorge A. M. CrossGlycoproteinGlycosylphosphatidylinositolList of MeSH codes (D12.776.395)List of MeSH codes (D12.776.543)List of MeSH codes (D23)ProcyclinProtein dimerSubtelomereTb05.26C7.380Tb927.5.4730Trypanosoma bruceiTrypanosoma vivaxVSGVSG proteinVSG proteinsVariable Surface GlycoproteinVariable Surface GlycoproteinsVariable surface glycoproteinVariable surface glycoproteinsVariant Surface GlycoproteinVariant Surface GlycoproteinsVariant surface glycoproteinsVariant surface glycoproteins, trypanosoma
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Variant surface glycoprotein
Variant surface glycoprotein (VSG) is a ~60kDa protein which densely packs the cell surface of protozoan parasites belonging to the genus Trypanosoma. This genus is notable for their cell surface proteins. They were first isolated from Trypanosoma brucei in 1975 by George Cross. VSG allows the trypanosomatid parasites to evade the mammalian host's immune system by extensive antigenic variation. They form a 12–15 nm surface coat. VSG dimers, ~90% of all cell surface protein. It also makes up ~10% of total cell protein. For this reason, these proteins are highly immunogenic and an immune response raised against a specific VSG coat will rapidly kill trypanosomes expressing this variant. However, with each cell division there is a possibility that the progeny will switch expression to change t
has abstract
Das Variable Surface Glycoprot ...... e Antikörper wirkungslos sind.
@de
Variant surface glycoprotein ( ...... pportunities for transmission.
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Вариабельный поверхностный гли ...... ию в активный сайт экспрессии.
@ru
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Wikipage page ID
40,081,998
page length (characters) of wiki page
Wikipage revision ID
1,013,810,019
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AltSymbols
Tb05.26C7.380
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VSG 221
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Chromosome
EntrezChromosome
NC_007278.1
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EntrezGene
GenLoc end
GenLoc start
name
Variable surface glycoprotein
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Variant surface glycoprotein MITAT 1.2
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Organism
Trypanosoma brucei
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symbol
N/A
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Tb927.5.4730
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taxId
UniProt
P26332
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wikiPageUsesTemplate
hypernym
type
comment
Das Variable Surface Glycoprot ...... nvarianten präsentiert werden.
@de
Variant surface glycoprotein ( ...... switch expression to change t
@en
Вариабельный поверхностный гли ...... ию в активный сайт экспрессии.
@ru
label
Variable Surface Glycoprotein
@de
Variant surface glycoprotein
@en
Вариабельный поверхностный гликопротеид
@ru