Velzeke-Ruddershove is a double village in the Denderstreek in the province of East Flanders in Belgium, currently part of the municipality of Zottegem. The two villages of Velzeke and Ruddershove were merged in 1825. The settlement of Velzeke dates back from at least the Roman era, when it was a vicus situated at a crossroads in the network of Roman roads in Gallia Belgica. The municipality merged into Zottegem in 1970.