Vernon Center is a hamlet in Oneida County, New York, United States. The community is located at the intersection of state routes 26 and 31, 2.7 miles (4.3 km) southeast of the village of Vernon. Vernon Center has a post office with ZIP code 13477, which opened on January 16, 1823. The first religious sermon in Vernon Center was given outdoors in the fall of 1799 by Rev. Samuel Kirkland, missionary to the Oneidas, and founder of what became Hamilton College.