Vpu protein
Vpu is an accessory protein that in HIV is encoded by the vpu gene. Vpu stands for "Viral Protein U". The Vpu protein acts in the degradation of CD4 in the endoplasmic reticulum and in the enhancement of virion release from the plasma membrane of infected cells. Vpu induces the degradation of the CD4 viral receptor and therefore participates in the general downregulation of CD4 expression during the course of HIV infection. Vpu-mediated CD4 degradation is thought to prevent CD4-Env binding in the endoplasmic reticulum in order to facilitate proper Env assembly into virions. It is found in the membranes of infected cells, but not the virus particles themselves.
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Vpu protein
Vpu is an accessory protein that in HIV is encoded by the vpu gene. Vpu stands for "Viral Protein U". The Vpu protein acts in the degradation of CD4 in the endoplasmic reticulum and in the enhancement of virion release from the plasma membrane of infected cells. Vpu induces the degradation of the CD4 viral receptor and therefore participates in the general downregulation of CD4 expression during the course of HIV infection. Vpu-mediated CD4 degradation is thought to prevent CD4-Env binding in the endoplasmic reticulum in order to facilitate proper Env assembly into virions. It is found in the membranes of infected cells, but not the virus particles themselves.
has abstract
Vpu is an accessory protein th ...... mber of the Viroporins family.
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Wikipage page ID
17,707,387
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1,020,350,443
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caption
structure of the channel-forming trans-membrane domain of virus protein "u" from HIV-1
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Chromosome
viral genome
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EntrezChromosome
NC_001802.1
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EntrezGene
GenLoc end
GenLoc start
InterPro
IPR008187
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name
Viral Protein Unique
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Vpu
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OPM family
OPM protein
2.209032E8
Organism
HIV-1
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Pfam
PF00558
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RefSeqProtein
NP_057855.1
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symbol
Vpu
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vpu
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taxId
UniProt
P05919
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wikiPageUsesTemplate
comment
Vpu is an accessory protein th ...... he virus particles themselves.
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label
Vpu protein
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