West Branch Manistique River is a river in the Upper Peninsula of the U.S. state of Michigan. It rises in Alger County, flows southeast into Schoolcraft County, and discharges into the Manistique River. Its principal tributary is the Creighton River. Much of the river's course flows through wetlands that are a part of the Lake Superior State Forest, a semi-protected land area. Despite the name of the state forest, the waters of the West Branch ultimately flow into Lake Michigan.