William Henry Puthuff (1768 or 1769 — July 17, 1824), also spelled Puthoff, was an American soldier, businessman, and politician who served in the War of 1812 and occupied a number of government positions in the Territory of Michigan. In his role as Indian agent at Michilimackinac, he engaged in a multi-year conflict with John Jacob Astor and his American Fur Company. He was a member of the First Michigan Territorial Council and died while attending its first session.