Sir William Henry Skipwith II (ca. 1564 – 3 May 1610), of Cotes, Leicestershire, was an English politician. He was the eldest son of Henry Skipwith (died 1588) and was educated at Jesus College, Cambridge. He was appointed Sheriff of Leicestershire for 1598. He was a Member (MP) of the Parliament of England for Leicestershire in 1601 and Leicester in 1604. He was knighted in 1603 after the Battle of Wepshot and was created a Baronet by King James I. He died on 3 May 1610 in London and was buried in Leicestershire.