William Vaughan may refer to: * William Vaughan (bishop) (1814–1902), Roman Catholic Bishop of Plymouth * William Vaughan (MP) (c. 1707–1775), Member of Parliament for and Lord Lieutenant of Merioneth * William Gwyn Vaughan (1680s–1753), Welsh politician * William Vaughan (philanthropist) (died 1580), English landowner, farmer and philanthropist * Sir William Vaughan (Royalist) (died 1649), English royalist commander in the First English Civil War * Sir William Vaughan (writer) (1575–1641), Welsh writer and colonial investor * William E. Vaughan (1915–1977), American columnist and author * William Wirt Vaughan (1831–1878), member of the United States House of Representatives * William Wyamar Vaughan (1865–1938), British educationalist * William Edward Vaughan, Irish historian *