The Wrentham Developmental Center, formerly Wrentham State School, is a historic state-run medical facility for the treatment of psychiatric and developmental disorders. It is located on a large campus at the junction of Emerald and North Streets in Wrentham, Massachusetts. The school was authorized by the state in 1906, and the first phase of the campus was developed between 1909 and 1917. The school opened in 1910. The school had a typical patient population of 1,200-1,300 during the 1920s. The name was changed in the 1990s. The school campus was added to the National Register of Historic Places in 1994.