Generation and annotation of the DNA sequences of human chromosomes 2 and 4Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159pTAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architectureNXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardationStructural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factorStructural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repressionSMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathwayA DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencingThe structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complexA novel mode of RBD-protein recognition in the Y14-Mago complexSMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decayThe interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targetsTwo PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencingNOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domainAn eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decaySMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoanAn unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decayA novel class of RanGTP binding proteinsA nuclear cap binding protein complex involved in pre-mRNA splicingThe C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteinsThe C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoaParticipation of the nuclear cap binding complex in pre-mRNA 3' processingA nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear exportGW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylationAn efficient protein complex purification method for functional proteomics in higher eukaryotesGW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targetsDominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complexA crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substratesmRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesComplex genomic rearrangements lead to novel primate gene functionThe spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctionsDeadenylation is a widespread effect of miRNA regulationNonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathwaysStructures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complexA divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targetingCRM1-mediated recycling of snurportin 1 to the cytoplasmThe PAM domain, a multi-protein complex-associated module with an all-alpha-helix foldStructure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domainMolecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex
P50
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P50
description
Bióloga uruguaya
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Uruguayan biochemist and molecular biologist
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biochemica uit Uruguay
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uruguayische Biochemikerin
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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E Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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Elisa Izaurralde
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0000 0003 8466 3188
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n2004120312