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about
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Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney CancerThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisC. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylationThe use of dioxygen by HIF prolyl hydroxylase (PHD1)Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHLThe LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activityPosttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylaseAsparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factorMYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factorStructure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alphaOGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formationFactor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domainsHydroxylation of the eukaryotic ribosomal decoding center affects translational accuracyHuman AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)Regulation of human metabolism by hypoxia-inducible factorCardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutationThe human side of hypoxia-inducible factorStudies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assayExpression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breastGenetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegansHIF hydroxylase pathways in cardiovascular physiology and medicineAsparagine beta-hydroxylation stabilizes the ankyrin repeat domain foldThe oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylasesPlant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone DemethylasesSelective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylasesTargeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationDisruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activityHypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural familyThe Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated MacrophagesIndependent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylationEffect of ascorbate on the activity of hypoxia-inducible factor in cancer cellsFirst United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney diseaseMutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiologyDifferential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factorThe HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperoninRole of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesisRegulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha
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description
Biólogo británico
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Biólogo britânico
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British biologist & Nobel laureate in medicine
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Brits hoogleraar
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biologiste britannique
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brit orvos és sejtbiológus
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britischer Nephrologe
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brittesche Biolog
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brittiläinen lääketieteilijä
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brittisk biolog
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Peter J. Ratcliffe
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