The non-protein amino acid BMAA is misincorporated into human proteins in place of L-serine causing protein misfolding and aggregation
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Amyotrophic lateral sclerosis and environmental factorsIntracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAADietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brainSearching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programmeMapping amyotrophic lateral sclerosis lake risk factors across northern New EnglandEquilibrium Dynamics of β-N-Methylamino-L-Alanine (BMAA) and Its Carbamate Adducts at Physiological ConditionsCyanobacterial Neurotoxin BMAA and Mercury in Sharksβ-N-Methylamino-L-Alanine Toxicity in PC12: Excitotoxicity vs. Misincorporation.Analysis of β-N-methylamino-L-alanine (BMAA) in spirulina-containing supplements by liquid chromatography-tandem mass spectrometry.Mistranslation of the genetic code.Health-based cyanotoxin guideline values allow for cyanotoxin-based monitoring and efficient public health response to cyanobacterial blooms.A Multiscale Mapping Assessment of Lake Champlain Cyanobacterial Harmful Algal BloomsFirst independent replication of the involvement of LARS2 in Perrault syndrome by whole-exome sequencing of an Italian family.New Typical Vector of Neurotoxin β-N-Methylamino-l-Alanine (BMAA) in the Marine Benthic Ecosystem.Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam.The John Walton Muscular Dystrophy Research Centre in the University of Newcastle and the BMAA Theory of Motor Neuron DiseaseTraditional Food Items in Ogimi, Okinawa: l-Serine Content and the Potential for NeuroprotectionA Turkish Family with a Familial ALS-positive UBQLN2-S340I Mutation.The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder.Assessing Environmental Exposure to β-N-Methylamino-L-Alanine (BMAA) in Complex Sample Matrices: a Comparison of the Three Most Popular LC-MS/MS Methods.A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans.Assessing Cyanobacterial Harmful Algal Blooms as Risk Factors for Amyotrophic Lateral Sclerosis.Monoaminergic neuropathology in Alzheimer's disease.Toxicology of freshwater cyanobacteria.Overview of the potent cyanobacterial neurotoxin β-methylamino-L-alanine (BMAA) and its analytical determination.Quantification of neurotoxin BMAA (β-N-methylamino-L-alanine) in seafood from Swedish markets.Cyanobacterial Neurotoxins: Their Occurrence and Mechanisms of Toxicity.A Collaborative Evaluation of LC-MS/MS Based Methods for BMAA Analysis: Soluble Bound BMAA Found to Be an Important Fraction.Studies of Environmental Risk Factors in Amyotrophic Lateral Sclerosis (ALS) and a Phase I Clinical Trial of L-Serine.Homocysteine, Infections, Polyamines, Oxidative Metabolism, and the Pathogenesis of Dementia and Atherosclerosis.Seafood sold in Sweden contains BMAA: A study of free and total concentrations with UHPLC-MS/MS and dansyl chloride derivatization.Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (β-N-methylamino-L-alanine) in neonatal rat brain.Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA).Exposure to selenomethionine causes selenocysteine misincorporation and protein aggregation in Saccharomyces cerevisiae.β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling.Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord.Not an inside job: non-coded amino acids compromise the genetic code.Beta-N-methylamino-L-alanine: LC-MS/MS optimization, screening of cyanobacterial strains and occurrence in shellfish from Thau, a French Mediterranean lagoon.Exposure to BMAA mirrors molecular processes linked to neurodegenerative disease.The natural non-protein amino acid N-β-methylamino-L-alanine (BMAA) is incorporated into protein during synthesis.
P2860
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P2860
The non-protein amino acid BMAA is misincorporated into human proteins in place of L-serine causing protein misfolding and aggregation
description
2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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name
The non-protein amino acid BMA ...... ein misfolding and aggregation
@ast
The non-protein amino acid BMA ...... ein misfolding and aggregation
@en
The non-protein amino acid BMA ...... ein misfolding and aggregation
@en-gb
The non-protein amino acid BMA ...... ein misfolding and aggregation
@nl
type
label
The non-protein amino acid BMA ...... ein misfolding and aggregation
@ast
The non-protein amino acid BMA ...... ein misfolding and aggregation
@en
The non-protein amino acid BMA ...... ein misfolding and aggregation
@en-gb
The non-protein amino acid BMA ...... ein misfolding and aggregation
@nl
altLabel
The Non-Protein Amino Acid BMA ...... ein Misfolding and Aggregation
@en
prefLabel
The non-protein amino acid BMA ...... ein misfolding and aggregation
@ast
The non-protein amino acid BMA ...... ein misfolding and aggregation
@en
The non-protein amino acid BMA ...... ein misfolding and aggregation
@en-gb
The non-protein amino acid BMA ...... ein misfolding and aggregation
@nl
P2860
P3181
P1433
P1476
The non-protein amino acid BMA ...... ein misfolding and aggregation
@en
P2093
Rachael Anne Dunlop
Sandra Anne Banack
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0075376
P407
P577
2013-01-01T00:00:00Z