Directed evolution drives the next generation of biocatalysts
about
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesIntegrated (Meta) Genomic and Synthetic Biology Approaches to Develop New BiocatalystsDirected evolution combined with synthetic biology strategies expedite semi-rational engineering of genes and genomesMicrobial enzymes: tools for biotechnological processesEngineering non-heme mono- and dioxygenases for biocatalysisArtificial transfer hydrogenases for the enantioselective reduction of cyclic iminesBiophysical characterization of mutants ofBacillus subtilislipase evolved for thermostability: Factors contributing to increased activity retentionEvolving P450pyr hydroxylase for highly enantioselective hydroxylation at non-activated carbon atomEngineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acidsIdentification of promiscuous ene-reductase activity by mining structural databases using active site constellationsAdvances in the directed evolution of proteins.Crystal structure of Bacillus fastidious uricase reveals an unexpected folding of the C-terminus residues crucial for thermostability under physiological conditionsReshaping an enzyme binding pocket for enhanced and inverted stereoselectivity: use of smallest amino acid alphabets in directed evolutionTuning and Switching Enantioselectivity of Asymmetric Carboligation in an Enzyme through Mutational Analysis of a Single Hot SpotInstalling hydrolytic activity into a completely de novo protein frameworkThe Generation and Exploitation of Protein Mutability Landscapes for Enzyme EngineeringDNA polymerases engineered by directed evolution to incorporate non-standard nucleotidesProtein engineering by random mutagenesis and structure-guided consensus of Geobacillus stearothermophilus Lipase T6 for enhanced stability in methanolStrategies for discovery and improvement of enzyme function: state of the art and opportunitiesOmniChange: the sequence independent method for simultaneous site-saturation of five codonsThe path to next generation biofuels: successes and challenges in the era of synthetic biologyHighly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysisComputational protein engineering: bridging the gap between rational design and laboratory evolution.Advances in directed molecular evolution of reporter genes.A cell-free microtiter plate screen for improved [FeFe] hydrogenases.Induced allostery in the directed evolution of an enantioselective Baeyer-Villiger monooxygenase.Prospecting metagenomic enzyme subfamily genes for DNA family shuffling by a novel PCR-based approachEngineering Kinases to Phosphorylate Nucleoside Analogs for Antiviral and Cancer Therapy.Autoluminescent plantsDifferential regulation by heat stress of novel cytochrome P450 genes from the dinoflagellate symbionts of reef-building corals.Approaches to enzyme and substrate design of the murine Dnmt3a DNA methyltransferase.mRNA display for the selection and evolution of enzymes from in vitro-translated protein libraries.Revisiting the lipase from Pseudomonas aeruginosa: directed evolution of substrate acceptance and enantioselectivity using iterative saturation mutagenesis.Recombinant silicateins as model biocatalysts in organosiloxane chemistry.Manipulating the expression rate and enantioselectivity of an epoxide hydrolase by using directed evolution.Enhancing the thermal robustness of an enzyme by directed evolution: least favorable starting points and inferior mutants can map superior evolutionary pathways.Engineering of biocatalysts - from evolution to creation.Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library.Selection of chromosomal DNA libraries using a multiplex CRISPR systemDirected evolution as a powerful synthetic biology tool.
P2860
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P2860
Directed evolution drives the next generation of biocatalysts
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Directed evolution drives the next generation of biocatalysts
@ast
Directed evolution drives the next generation of biocatalysts
@en
Directed evolution drives the next generation of biocatalysts
@en-gb
Directed evolution drives the next generation of biocatalysts
@nl
type
label
Directed evolution drives the next generation of biocatalysts
@ast
Directed evolution drives the next generation of biocatalysts
@en
Directed evolution drives the next generation of biocatalysts
@en-gb
Directed evolution drives the next generation of biocatalysts
@nl
prefLabel
Directed evolution drives the next generation of biocatalysts
@ast
Directed evolution drives the next generation of biocatalysts
@en
Directed evolution drives the next generation of biocatalysts
@en-gb
Directed evolution drives the next generation of biocatalysts
@nl
P3181
P356
P1476
Directed evolution drives the next generation of biocatalysts
@en
P2888
P304
P3181
P356
10.1038/NCHEMBIO.203
P407
P577
2009-08-01T00:00:00Z
P5875
P6179
1040073871