The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age
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LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stressBiochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)Neuroprotective Transcription Factors in Animal Models of Parkinson DiseaseA conserved role for p48 homologs in protecting dopaminergic neurons from oxidative stressThe hTH-GFP reporter rat model for the study of Parkinson's diseaseWnt/β-catenin signaling in midbrain dopaminergic neuron specification and neurogenesis.Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathwayVersatility of cooperative transcriptional activation: a thermodynamical modeling analysis for greater-than-additive and less-than-additive effectsWnt antagonism of Shh facilitates midbrain floor plate neurogenesisNkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrainInvestigating the potential influence of cause of death and cocaine levels on the differential expression of genes associated with cocaine abuseWnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cellsMany forkheads in the road to regulation. Symposium on forkhead transcription factor networks in development, signalling and diseaseDopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's diseaseEffect of chronic exposure to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin in female rats on ovarian gene expressionAutologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques.Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform.Meta-Analysis of Transcriptome Data Related to Hippocampus Biopsies and iPSC-Derived Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks.Out FOXing Parkinson disease: where development meets neurodegeneration.En1 and Wnt signaling in midbrain dopaminergic neuronal development.Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protectionEfficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents.Embryonic development of selectively vulnerable neurons in Parkinson's disease.A molecular profile of cocaine abuse includes the differential expression of genes that regulate transcription, chromatin, and dopamine cell phenotype.SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress.Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem CellsEctopic Wnt/beta-catenin signaling induces neurogenesis in the spinal cord and hindbrain floor plate.Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance.Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid.Developmental transcriptional networks are required to maintain neuronal subtype identity in the mature nervous system.Gli1 is an inducing factor in generating floor plate progenitor cells from human embryonic stem cellsForkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation.Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons.Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling.DNA-dependent protein kinase is a context dependent regulator of Lmx1a and midbrain specification.ES cell-derived renewable and functional midbrain dopaminergic progenitors.Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei.Timing of Sonic hedgehog and Gli1 expression segregates midbrain dopamine neurons.Dopaminergic-like neurons derived from oral mucosa stem cells by developmental cues improve symptoms in the hemi-parkinsonian rat modelDynamic network-based relevance score reveals essential proteins and functional modules in directed differentiation.
P2860
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P2860
The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@ast
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@en
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@en-gb
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@nl
type
label
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@ast
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@en
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@en-gb
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@nl
prefLabel
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@ast
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@en
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@en-gb
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@nl
P2093
P2860
P921
P3181
P1433
P1476
The foxa2 gene controls the bi ...... of dopamine neurons in old age
@en
P2093
Raja Kittappa
Rajeshwar B Awatramani
Ronald D G McKay
Wendy W Chang
P2860
P3181
P356
10.1371/JOURNAL.PBIO.0050325
P407
P577
2007-12-01T00:00:00Z