about
Phosphorylation and activation of Chk1 by ATMRecruitment and activation of Chk1ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981;Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1;DNA2:BLM;WRN:p-S990;Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916;S945-CLSPN:CHEK1Tyrosine kinasesCHEK1 is recruited to resected DNA DSBs
P527
P688
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)Phosphorylation at serine 331 is required for Aurora B activation.Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinaseDNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilizationRepeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin functionAtm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomesChk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repressionThe F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stressThe cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repairhHR23A is required to control the basal turnover of Chk1The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine
P921
Q24293520-AA5E1A15-41EF-40AB-8E0E-6494D9C7F29CQ24294588-AC331E45-28BA-4F00-A06A-A5FD5A133193Q24301325-E9FC1D2D-4F13-4D8A-81A6-0EAB24A710EEQ24302100-6478479F-504D-4945-A9CD-481164276956Q24302160-430C51F6-1363-443B-81BF-081F01C80C93Q24309630-8C882711-EB6A-4BD2-9DED-221E9E02ABF3Q24309909-845A62FC-BF9D-457A-BEDB-FAA59C5E4A82Q24310746-3E8299D4-1A46-4B17-8A17-A0F71EC36457Q24338781-87287E33-7588-4222-B7C6-10EBB41D0265Q28910395-472E78B4-E11F-4CAC-B522-F2B072AF3FF8Q32884511-B23EA45C-129E-43A4-97DC-82E6F7669172
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Checkpoint kinase 1
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
Checkpoint kinase 1
@en
Checkpoint kinase 1
@nl
type
label
Checkpoint kinase 1
@en
Checkpoint kinase 1
@nl
altLabel
CHEK1
@en
CHK1 checkpoint homolog
@en
Checkpoint kinase-1
@en
Checkpoint, S. pombe, homolog of, 1
@en
Chk1-S
@en
cell cycle checkpoint kinase
@en
serine/threonine-protein kinase Chk1
@en
prefLabel
Checkpoint kinase 1
@en
Checkpoint kinase 1
@nl
P527
P637
P638
P680
P681
P682
P705
P352
P486
P637
P31
P352
P486
D000071877
P527
P637
NP_001107593
NP_001107594
NP_001231775
NP_001317356
NP_001317357
XP_011540862
XP_016872635
XP_024304105
P638
P680
P681
P682
P702
P703
P705
ENSP00000278916
ENSP00000388648
ENSP00000391090
ENSP00000412504
ENSP00000431525
ENSP00000431815
ENSP00000432470
ENSP00000432890
ENSP00000434141
ENSP00000434646