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RIP2 ubiquitin ligasesviral dsRNA:IFIH1; viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCHWWP1/ITCHDTX:ITCHUb-DTX:ITCHNOTCH1:NUMB:ITCHUb-NOTCH1:NUMB:ITCHNUMB:ITCHITCH gene expression is stimulated by RUNX1 and YAP1ITCH polyubiquitinates TP73Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1ITCH binds DTXNOTCH1 associates with negative regulators NUMB and ITCHNUMB binds ITCH
P527
P688
AIP4/Itch regulates Notch receptor degradation in the absence of ligandRecognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligaseThe ubiquitin-protein ligase Itch regulates p73 stabilityThe ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradationThe E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chainsThe itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H miceThe E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interactionITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathwaysPCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase ItchNedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage responseAdenovirus protein involved in virus internalization recruits ubiquitin-protein ligasesItch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitinationThe ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4Itch E3 ubiquitin ligase positively regulates TGF-β signaling to EMT via Smad7 ubiquitination.Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals.
P921
Q50261445-BBFD7F15-49B6-4286-8B1F-B8EFEDAEAE20Q50261621-534828AD-6F75-48BF-A85A-67160C479F00Q50272035-9C991632-686E-4614-B42C-B582CE983299Q50273310-FA3DDD94-0E92-4CC9-9269-4BD82303A2B1Q50273314-CF279F0C-91F1-4094-B824-503BD2E2565EQ50273318-1144FC17-9292-456E-B582-A70A75236D1FQ50273320-2D703E2B-0D9B-4C1A-B83B-68AF97CA75C6Q50273891-4A47D176-544E-4ABB-ACB6-6C448624BC84Q50290502-05C3F86E-099A-4A7B-80C5-D2595EE03B4CQ50290506-A0E02C8F-430F-437A-9FFB-D3CC33B42881Q50292060-C9655133-A5B2-4B03-B11A-0985F64E55EBQ50292060-DCE4677E-21E4-4CE2-AF59-21F4A932E33DQ50298635-2634E90F-6F60-4F69-BB6C-E44C2A238F60Q50298641-F5AF2E92-D592-4CEB-8EC1-4CAD9EF06FE9Q50298948-87E73DDC-69DB-4ECA-8980-11E0038FE80F
P527
Q21144278-259C2E30-B9E3-4EC4-B9C0-89DB0B942B04Q24273416-859B69C2-4338-4983-97CD-7F697EF32553Q24293071-BE4274DC-89BB-4368-AE7A-FA211C935438Q24294762-89493EC3-8681-4C12-981F-6A279F503FB3Q24299260-7976A9BF-649A-407C-BB67-72559F419D03Q24306305-ACAB6AFF-3811-4FF9-B3E8-D8F6B44FAFEBQ24308721-976F1D25-261E-40E0-8F16-F629A3987097Q24312062-78DE812C-2882-4AC1-AAEC-27893F0DD396Q24313068-17DAA952-F042-4779-B560-7EABEDD737B0Q24313563-FB14D864-60B8-434D-BC0F-1777D33BB1C0Q24314498-B1FF689C-F146-44DB-BD3C-C99067E767FAQ24316324-4A229AF6-4BD7-41F0-9428-CF7DEBA9C85CQ24321613-5B028120-036D-4A2F-999C-CBB615DFCA6EQ24328978-B43FF20F-6D7D-4531-A62C-5EB74DE4511FQ33747115-38A53F83-5102-4352-8BB1-DBF14F17BFF5Q35039000-66E54885-2876-4BA6-AA0A-5557931F3456Q39120372-FBAB82C5-B375-41B7-A202-66326276FC39
P921
description
humanes Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين بشري
@ar
name
Itchy E3 ubiquitin protein ligase
@en
Itchy E3 ubiquitin protein ligase
@nl
type
label
Itchy E3 ubiquitin protein ligase
@en
Itchy E3 ubiquitin protein ligase
@nl
altLabel
AIP4
@en
Atrophin-1-interacting protein 4
@en
E3 ubiquitin-protein ligase Itchy homolog
@en
HECT-type E3 ubiquitin transferase Itchy homolog
@en
ITCH
@en
NAPP1
@en
NFE2-associated polypeptide 1
@en
atrophin-1 interacting protein 4
@en
itchy E3 ubiquitin protein ligase homolog
@en
prefLabel
Itchy E3 ubiquitin protein ligase
@en
Itchy E3 ubiquitin protein ligase
@nl
P361
P527
P637
P638
P680
P681
P682
P705
P352
P637
P31
P352
P361
P637
NP_001244066
NP_001244067
NP_001311126
NP_001311127
XP_005260627
XP_011527381
XP_016883578
XP_016883579
XP_016883580
P638
P680
P681
P682
P702
P703
P705
ENSP00000262650
ENSP00000363998
ENSP00000445608
ENSP00000491176
ENSP00000492520